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Literature summary for 3.1.1.89 extracted from

  • Ikehara, T.; Ikehara, S.; Imamura, S.; Shinjo, F.; Yasumoto, T.
    Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B) (2007), Biochem. Biophys. Res. Commun., 354, 1052-1057.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[protein phosphatase 2A catalytic subunit]-leucine methyl ester + H2O
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Homo sapiens [protein phosphatase 2A catalytic subunit]-leucine + methanol reversible methylation and demethylation at C-terminal residue Leu309. The activity of protein phosphatase 2A is largely unaffected by the addition of enzyme. Mutant versions of substrate protein phosphatase 2A containing an alanine residue in place of Leu309, and a deletion of Leu309 both exhibit phosphatase activity r

Synonyms

Synonyms Comment Organism
PME-1
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Homo sapiens
PP2A methylesterase
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Homo sapiens