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Literature summary for 3.1.1.89 extracted from
- Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells (2010), J. Neurochem., 115, 1455-1465.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Neuro-2a cell | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | stable overexpression of PME-1 or of the methylation-site mutant L309DELTA of substrate protein phosphatase 2A C subunit block N2a cell differentiation and neurite formation mediated by leucine carboxyl transferase LCMT1. Selective PME-1 knockdown in N2a cells promotes the formation of very elongated and thin neurite-like projections | Mus musculus |
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Release 2023.1 (January 2023)
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