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Literature summary for 3.1.1.88 extracted from

  • Zhang, L.; Shi, J.; Shi, X.; Liang, P.; Gao, J.; Gao, X.
    Quantitative and qualitative changes of the carboxylesterase associated with beta-cypermethrin resistance in the housefly, Musca domestica (Diptera: Muscidae) (2010), Comp. Biochem. Physiol. B, 156, 6-11.
    View publication on PubMed
Search for more literature for 3.1.1.88

Cloned(Commentary)

Cloned (Comment) Organism
gene MdalphaE7, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis Musca domestica

Organism

Organism UniProt Comment Textmining
Musca domestica
-
 gene MdalphaE7
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R/S)-alpha-cyano (6-methoxy-2-naphthyl)-methyl(R/S)-trans/cis-3-(2,2-dibromovinyl)-2,2-dimethyl cyclopropane carboxylate + H2O deltamethrin-like substrate Musca domestica ?
-
 ?
(R/S)-alpha-cyano (6-methoxy-2-naphthyl)-methyl(R/S)-trans/cis-3-(2,2-dichlorovinyl)-2,2-dimethyl cyclopropane carboxylate + H2O cypermethrin-like substrate Musca domestica ?
-
 ?
beta-cypermethrin + H2O
-
 Musca domestica ?
-
 ?
deltamethrin + H2O
-
 Musca domestica 3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
 ?
additional information synthesis of two alpha-cyanoester substrates as surrogates for beta-cypermethrin and deltamethrin. The pyrethroid hydrolase activity of carboxylesterases from the pyrethroid resistant strain hydrolyzing cypermethrin-like or deltamethrin-like substrates is 9.05fold and 13.53fold more efficiently than those from the pyrethroid susceptible strain, respectively Musca domestica ?
-
 ?

Subunits

Subunits Comment Organism
More MdalphaE7 structure homology modelling, overview Musca domestica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Musca domestica

General Information

General Information Comment Organism
physiological function overexpression of gene MdalphaE7 in CRR strains leads to resistance versus pyrethroid Musca domestica