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Literature summary for 3.1.1.81 extracted from

  • Liao, R.Z.; Yu, J.G.; Himo, F.
    Reaction mechanism of the dinuclear zinc enzyme N-acyl-L-homoserine lactone hydrolase: a quantum chemical study (2009), Inorg. Chem., 48, 1442-1448.
    View publication on PubMed
Search for more literature for 3.1.1.81

Crystallization (Commentary)

Crystallization (Comment) Organism
analysis of crystal structures of the enzyme with bound inhibitor N-homoserine lactone, and of the active site and substrate bound enzyme, modeling, overview Bacillus thuringiensis

Inhibitors

Inhibitors Comment Organism Structure
L-homoserine lactone enzyme binding structure, PDB ID 2BR6, overview Bacillus thuringiensis

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can substitute for Zn2+ Bacillus thuringiensis
Co2+ can substitute for Zn2+ Bacillus thuringiensis
Mn2+ can substitute for Zn2+ Bacillus thuringiensis
Zn2+ a dinuclear zinc enzyme, the metal ions are bound to the active site. The zinc 2 ion is responsible for the electrostatic stabilization of the tetrahedral intermediate, while zinc 1 is responsible for the stabilization of the leaving group Bacillus thuringiensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an N-acyl-L-homoserine lactone + H2O Bacillus thuringiensis
-
 an N-acyl-L-homoserine
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus thuringiensis P0CJ63
-
-

Reaction

Reaction Comment Organism Reaction ID
an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine reaction mechanism, and active site structure and function modeling, Asp108 residue, and not Tyr194, shuttles the proton during the reaction, overview Bacillus thuringiensis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an N-acyl-L-homoserine lactone + H2O
-
 Bacillus thuringiensis an N-acyl-L-homoserine
-
 ?
additional information substrate binding analysis by quantum mechanics/molecular mechanics (QM/MM) molecular dynamics simulations, overview Bacillus thuringiensis ?
-
 ?
N-hexanoyl-L-homoserine lactone + H2O
-
 Bacillus thuringiensis N-hexanoyl-L-homoserine
-
 ?

Synonyms

Synonyms Comment Organism
AHL lactonase
-
 Bacillus thuringiensis
N-acyl-L-homoserine lactone hydrolase
-
 Bacillus thuringiensis