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Literature summary for 3.1.1.8 extracted from

  • Mohammed, A.; Sneathen, J.; Frojen, S.G.; Kuo, L.; Dupureur, C.M.
    Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate (2017), Bioorg. Med. Chem., 25, 3053-3058 .
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
cyclophostin
-
 Equus caballus
leptophos
-
 Equus caballus
methamidophos
-
 Equus caballus
O-ethyl-S-2-diisopropylaminoethylmethylphosphonothiolate
-
 Equus caballus
paraoxon
-
 Equus caballus
R-DEPP O,R-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,R-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging Equus caballus
S-DEPP O,S-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,S-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging. Pralidoxime, a common rescue agent, affects a modest recovery of eqBChE from treatment with S-DEPP. S-DEPP inhibition is practically irreversible. Kinetic analysis of S-DEPP with cholinesterases Equus caballus
sarin
-
 Equus caballus
soman
-
 Equus caballus
Tabun
-
 Equus caballus
thiomethylcyclosarin
-
 Equus caballus
thiomethylsarin
-
 Equus caballus
thiomethylsoman
-
 Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus P81908
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Equus caballus
-
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
butyrylcholinesterase
-
 Equus caballus
eqBChE
-
 Equus caballus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Equus caballus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.007
-
 S-DEPP pH 8.0, 25°C Equus caballus
0.15
-
 R-DEPP pH 8.0, 25°C Equus caballus