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Literature summary for 3.1.1.8 extracted from

  • Sultana, N.; Sarfraz, M.; Tanoli, S.T.; Akram, M.S.; Sadiq, A.; Rashid, U.; Tariq, M.I.
    Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases (2017), Bioorg. Chem., 72, 256-267 .
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1,2,3,4-tetrahydroacridin-9-amine
-
 Equus caballus
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
-
 Equus caballus
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
2,3-dihydroquinazolin-4(1H)-one
-
 Equus caballus
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
 Equus caballus
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
 Equus caballus
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
-
 Equus caballus
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
-
 Equus caballus
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
-
 Equus caballus
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
-
 Equus caballus
bistacrine
-
 Equus caballus
donepezil
-
 Equus caballus
galantamine
-
 Equus caballus
additional information synthesis, crystal structure determination, biological screening, and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases, structure-activity relationships, overview Equus caballus
N-[4-[4-(1,3-benzothiazol-2-yl)phenoxy]butyl]-6-chloro-1,2,3,4-tetrahydroacridin-9-amine
-
 Equus caballus
tacrine-caffeic acid hybrid
-
 Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus P81908
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Equus caballus
-
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Equus caballus
butyrylcholinesterase
-
 Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
 pH and temperature not specified in the publication Equus caballus 2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
0.00039
-
 pH and temperature not specified in the publication Equus caballus 2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
0.00156
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
0.0016
-
 pH and temperature not specified in the publication Equus caballus 6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
0.00248
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
0.00357
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.00376
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.00448
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0045
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0046
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.0065
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.01056
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
0.01102
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0115
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0165
-
 pH and temperature not specified in the publication Equus caballus 1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0189
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0196
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0196
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0205
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0217
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0224
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0237
-
 pH and temperature not specified in the publication Equus caballus 1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0332
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0354
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0418
-
 pH and temperature not specified in the publication Equus caballus 1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
0.0445
-
 pH and temperature not specified in the publication Equus caballus 1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.046
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0502
-
 pH and temperature not specified in the publication Equus caballus 1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
0.0614
-
 pH and temperature not specified in the publication Equus caballus 1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0709
-
 pH and temperature not specified in the publication Equus caballus 1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0974
-
 pH and temperature not specified in the publication Equus caballus 2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0998
-
 pH and temperature not specified in the publication Equus caballus 1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.1069
-
 pH and temperature not specified in the publication Equus caballus 1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.1072
-
 pH and temperature not specified in the publication Equus caballus 1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
0.1261
-
 pH and temperature not specified in the publication Equus caballus 1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one