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Literature summary for 3.1.1.8 extracted from
- Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase (2010), Bioorg. Med. Chem. Lett., 20, 3254-3258.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine | - |
Equus caballus |  |
| 10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine | - |
Equus caballus | |
| 4-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylbutan-1-amine | - |
Equus caballus | |
| 4-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylbutan-1-amine | - |
Equus caballus | |
| 5-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylpentan-1-amine | - |
Equus caballus | |
| 5-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylpentan-1-amine | - |
Equus caballus | |
| 6-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylhexan-1-amine | - |
Equus caballus | |
| 6-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylhexan-1-amine | - |
Equus caballus | |
| 8-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyloctan-1-amine | - |
Equus caballus | |
| 8-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyloctan-1-amine | - |
Equus caballus | |
| N,N-dibutyl-10-[4-[(diethylamino)methyl]phenoxy]decan-1-amine | - |
Equus caballus | |
| N,N-dibutyl-4-[4-[(diethylamino)methyl]phenoxy]butan-1-amine | - |
Equus caballus | |
| N,N-dibutyl-5-[4-[(diethylamino)methyl]phenoxy]pentan-1-amine | - |
Equus caballus | |
| N,N-dibutyl-6-[4-[(diethylamino)methyl]phenoxy]hexan-1-amine | - |
Equus caballus | |
| N,N-dibutyl-8-[4-[(diethylamino)methyl]phenoxy]octan-1-amine | - |
Equus caballus | |
| N-ethyl-N-(4-[[10-(4-ethylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[10-(4-methylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[10-(piperidin-1-yl)decyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[10-(pyrrolidin-1-yl)decyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[5-(4-ethylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[5-(4-methylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[5-(piperidin-1-yl)pentyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[5-(pyrrolidin-1-yl)pentyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[6-(4-ethylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[6-(4-methylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[6-(piperidin-1-yl)hexyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[6-(pyrrolidin-1-yl)hexyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[8-(4-ethylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[8-(4-methylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[8-(piperidin-1-yl)octyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-(4-[[8-(pyrrolidin-1-yl)octyl]oxy]benzyl)ethanamine | - |
Equus caballus | |
| N-ethyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl]ethanamine | - |
Equus caballus | |
| N-ethyl-N-[4-[2-(piperidin-1-yl)ethoxy]benzyl]ethanamine | - |
Equus caballus | |
| N-ethyl-N-[4-[4-(4-methylpiperazin-1-yl)butoxy]benzyl]ethanamine | - |
Equus caballus | |
| N-ethyl-N-[4-[4-(piperidin-1-yl)butoxy]benzyl]ethanamine | - |
Equus caballus | |
| N-ethyl-N-[4-[4-(pyrrolidin-1-yl)butoxy]benzyl]ethanamine | - |
Equus caballus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Equus caballus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Equus caballus |
| butyrylcholinesterase | - |
Equus caballus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000073 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[8-(piperidin-1-yl)octyl]oxy]benzyl)ethanamine | |
| 0.0000091 | - |
pH and temperature not specified in the publication | Equus caballus | 8-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyloctan-1-amine | |
| 0.000011 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[8-(4-methylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine | |
| 0.000014 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[8-(4-ethylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine | |
| 0.000015 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[8-(pyrrolidin-1-yl)octyl]oxy]benzyl)ethanamine | |
| 0.000015 | - |
pH and temperature not specified in the publication | Equus caballus | N,N-dibutyl-10-[4-[(diethylamino)methyl]phenoxy]decan-1-amine | |
| 0.000017 | - |
pH and temperature not specified in the publication | Equus caballus | N,N-dibutyl-8-[4-[(diethylamino)methyl]phenoxy]octan-1-amine | |
| 0.000026 | - |
pH and temperature not specified in the publication | Equus caballus | 10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine | |
| 0.000027 | - |
pH and temperature not specified in the publication | Equus caballus | 10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine | |
| 0.000033 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[10-(4-methylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine | |
| 0.000048 | - |
pH and temperature not specified in the publication | Equus caballus | 8-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyloctan-1-amine | |
| 0.000068 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[10-(pyrrolidin-1-yl)decyl]oxy]benzyl)ethanamine | |
| 0.000078 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[10-(piperidin-1-yl)decyl]oxy]benzyl)ethanamine | |
| 0.00019 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[10-(4-ethylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine | |
| 0.00023 | - |
pH and temperature not specified in the publication | Equus caballus | N,N-dibutyl-6-[4-[(diethylamino)methyl]phenoxy]hexan-1-amine | |
| 0.00067 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[5-(piperidin-1-yl)pentyl]oxy]benzyl)ethanamine | |
| 0.00071 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-[4-[4-(piperidin-1-yl)butoxy]benzyl]ethanamine | |
| 0.00128 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[6-(pyrrolidin-1-yl)hexyl]oxy]benzyl)ethanamine | |
| 0.00134 | - |
pH and temperature not specified in the publication | Equus caballus | 6-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylhexan-1-amine | |
| 0.00137 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[6-(piperidin-1-yl)hexyl]oxy]benzyl)ethanamine | |
| 0.0014 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-[4-[4-(pyrrolidin-1-yl)butoxy]benzyl]ethanamine | |
| 0.00154 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[5-(pyrrolidin-1-yl)pentyl]oxy]benzyl)ethanamine | |
| 0.00166 | - |
pH and temperature not specified in the publication | Equus caballus | 6-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylhexan-1-amine | |
| 0.00178 | - |
pH and temperature not specified in the publication | Equus caballus | 5-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylpentan-1-amine | |
| 0.0019 | - |
pH and temperature not specified in the publication | Equus caballus | N,N-dibutyl-5-[4-[(diethylamino)methyl]phenoxy]pentan-1-amine | |
| 0.0022 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[6-(4-ethylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine | |
| 0.00252 | - |
pH and temperature not specified in the publication | Equus caballus | N,N-dibutyl-4-[4-[(diethylamino)methyl]phenoxy]butan-1-amine | |
| 0.00274 | - |
pH and temperature not specified in the publication | Equus caballus | 4-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylbutan-1-amine | |
| 0.00308 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[5-(4-ethylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine | |
| 0.00376 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[6-(4-methylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine | |
| 0.00442 | - |
pH and temperature not specified in the publication | Equus caballus | 5-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylpentan-1-amine | |
| 0.00935 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-(4-[[5-(4-methylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine | |
| 0.00973 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-[4-[4-(4-methylpiperazin-1-yl)butoxy]benzyl]ethanamine | |
| 0.0101 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-[4-[2-(piperidin-1-yl)ethoxy]benzyl]ethanamine | |
| 0.01169 | - |
pH and temperature not specified in the publication | Equus caballus | 4-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylbutan-1-amine | |
| 0.02027 | - |
pH and temperature not specified in the publication | Equus caballus | N-ethyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl]ethanamine | |
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