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Literature summary for 3.1.1.8 extracted from
- Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata (2009), Arch. Pharm. Res., 32, 1399-1408.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 15alpha,16alpha-epoxy-17-hydroxy-ent-kauran-19-oic acid | - |
Equus caballus |  |
| 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid | - |
Equus caballus | |
| 16alpha,17-dihydroxy-ent-kauran-19-oic acid | - |
Equus caballus | |
| 17-hydroxy-ent-kaur-15-en-19-oic acid | - |
Equus caballus | |
| 18-nor-ent-Kaur-16-ene-4 beta-ol | - |
Equus caballus | |
| 18-nor-ent-pimara-8(14),15-diene-4 beta-ol | - |
Equus caballus | |
| 7-oxo-ent-pimara-8(14),15-diene-19-oic acid | - |
Equus caballus | |
| ent-kaur-16-en-19-oic-acid | - |
Equus caballus | |
| ent-pimar-15-en-8 alpha, 19-diol | - |
Equus caballus | |
| ent-pimara-8(14),15-diene-19-oic acid | - |
Equus caballus | |
| ent-pimara-8(14),15-diene-19-ol | - |
Equus caballus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Equus caballus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylthiocholine chloride + H2O | - |
Equus caballus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Equus caballus |
| butyrylcholinesterase | - |
Equus caballus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at room temperature | Equus caballus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Equus caballus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00758 | - |
- |
Equus caballus | ent-pimar-15-en-8 alpha, 19-diol | |
| 0.017 | - |
- |
Equus caballus | 16alpha,17-dihydroxy-ent-kauran-19-oic acid | |
| 0.0178 | - |
- |
Equus caballus | 18-nor-ent-pimara-8(14),15-diene-4 beta-ol | |
| 0.019 | - |
- |
Equus caballus | 17-hydroxy-ent-kaur-15-en-19-oic acid | |
| 0.02239 | - |
- |
Equus caballus | ent-kaur-16-en-19-oic-acid | |
| 0.025 | - |
- |
Equus caballus | 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid | |
| 0.042 | - |
- |
Equus caballus | ent-pimara-8(14),15-diene-19-ol | |
| 0.047 | - |
- |
Equus caballus | 15alpha,16alpha-epoxy-17-hydroxy-ent-kauran-19-oic acid | |
| 0.072 | - |
- |
Equus caballus | 18-nor-ent-Kaur-16-ene-4 beta-ol | |
| 0.094 | - |
- |
Equus caballus | 7-oxo-ent-pimara-8(14),15-diene-19-oic acid | |
| 0.107 | - |
- |
Equus caballus | ent-pimara-8(14),15-diene-19-oic acid | |
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Release 2023.1 (January 2023)
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