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Literature summary for 3.1.1.8 extracted from

  • Gao, Y.; LaFleur, D.; Shah, R.; Zhao, Q.; Singh, M.; Brimijoin, S.
    An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties (2008), Chem. Biol. Interact., 175, 83-87.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.8

Protein Variants

Protein Variants Comment Organism
additional information construction of a a quadruple mutant cocaine hydrolase CocH with improved catalytic efficiency for cocaine, the mutant enzyme is expressed as albumin fusion protein and introduced in rats, male and female Wistar rats, showing enzyme activity but also high enzyme decay rates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylthiocholine + H2O Homo sapiens
-
 acetate + thiocholine
-
 ?
butyrylthiocholine + H2O Homo sapiens
-
 butyrate + thiocholine
-
 ?
cocaine + H2O Homo sapiens
-
 ecgonine methyl ester + benzoate
-
 ?
additional information Homo sapiens butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Homo sapiens acetate + thiocholine
-
 ?
butyrylthiocholine + H2O
-
 Homo sapiens butyrate + thiocholine
-
 ?
cocaine + H2O
-
 Homo sapiens ecgonine methyl ester + benzoate
-
 ?
additional information butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
monomer BChE tetrameric forms are much longer-lived than monomers Homo sapiens
tetramer BChE tetrameric forms are much longer-lived than monomers Homo sapiens

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens