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Literature summary for 3.1.1.8 extracted from

  • Petroianu, G.A.; Nurulain, S.M.; Arafat, K.; Rajan, S.; Hasan, M.Y.
    Effect of pyridostigmine, pralidoxime and their combination on survival and cholinesterase activity in rats exposed to the organophosphate paraoxon (2006), Arch. Toxicol., 80, 777-84.
    View publication on PubMed

Application

Application Comment Organism
medicine both pyridostigmine and pralidoxime significally decrease organophosphate induced mortality of a LD75 dose of paraoxon by inhibition of enzyme. Decrease in mortality when using both pyridostigmine and pralidoxime together is less than that achieved with their single use Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
pralidoxime significally decreases organophosphate induced mortality of a LD75 dose of paraoxon Rattus norvegicus
pyridostigmine significally decreases organophosphate induced mortality of a LD75 dose of paraoxon Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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