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Literature summary for 3.1.1.8 extracted from

  • Wierdl, M.; Morton, C.L.; Danks, M.K.; Potter, P.M.
    Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation (2000), Biochem. Pharmacol., 59, 773-781.
    View publication on PubMed
Search for more literature for 3.1.1.8

Cloned(Commentary)

Cloned (Comment) Organism
-
 Equus caballus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000106
-
 butyrylthiocholine pH 7.4, 37°C Equus caballus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 after removal of carbohydrate residues, SDS-PAGE Equus caballus
95000
-
 2 * 95000, SDS-PAGE Equus caballus
200000
-
 glycosylated protein, SDS-PAGE Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus Q9N1N9
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Equus caballus

Purification (Commentary)

Purification (Comment) Organism
-
 Equus caballus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Equus caballus
-
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O anticancer drug irinotecan CPT-11 Equus caballus 7-ethyl-10-hydroxycamptothecin + ?
-
 ?
butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?
propionylthiocholine + H2O
-
 Equus caballus thiocholine + propionate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 95000, SDS-PAGE Equus caballus