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Literature summary for 3.1.1.79 extracted from

  • Ogiyama, T.; Yamaguchi, M.; Kurikawa, N.; Honzumi, S.; Terayama, K.; Nagaoka, N.; Yamamoto, Y.; Kimura, T.; Sugiyama, D.; Inoue, S.I.
    Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor (2017), Bioorg. Med. Chem., 25, 4817-4828 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(5-fluoro-2-[([6-[4-(trifluoromethyl)phenoxy]pyridin-3-yl]carbonyl)amino]phenyl)boronic acid potent inhibitor, in vitro and in cell with high selectivity for cholinesterases AChE and BuChE. The compound exhibits antilipolytic effect in rats at 1 mg/kg p.o. and does not show bioactivation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000068
-
pH 7.3, 37°C Homo sapiens (5-fluoro-2-[([6-[4-(trifluoromethyl)phenoxy]pyridin-3-yl]carbonyl)amino]phenyl)boronic acid