Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.79 extracted from

  • Vasilieva, E.; Dutta, S.; Malla, R.K.; Martin, B.P.; Spilling, C.D.; Dupureur, C.M.
    Rat hormone sensitive lipase inhibition by cyclipostins and their analogs (2015), Bioorg. Med. Chem., 23, 944-952 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.79

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
cis-cyclipostin R
-
 Rattus norvegicus
methyl 2-(hexadecyloxy)-4-methyl-6,7-dihydro-1,3,2-dioxaphosphepine-5-carboxylate 2-oxide
-
 Rattus norvegicus
trans-cyclipostin P irreversible Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triolein + H2O
-
 Rattus norvegicus dioleoylglycerol + oleate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000004
-
 trans-cyclipostin P pH 7.4, 37°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000025
-
 pH 7.4, 37°C Rattus norvegicus trans-cyclipostin P
0.00006
-
 pH 7.4, 37°C Rattus norvegicus methyl 2-(hexadecyloxy)-4-methyl-6,7-dihydro-1,3,2-dioxaphosphepine-5-carboxylate 2-oxide
0.000075
-
 pH 7.4, 37°C Rattus norvegicus cis-cyclipostin R