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Literature summary for 3.1.1.79 extracted from

  • Langfort, J.; Jagsz, S.; Dobrzyn, P.; Brzezinska, Z.; Klapcinska, B.; Galbo, H.; Gorski, J.
    Testosterone affects hormone-sensitive lipase (HSL) activity and lipid metabolism in the left ventricle (2010), Biochem. Biophys. Res. Commun., 399, 670-676.
    View publication on PubMed
Search for more literature for 3.1.1.79

Activating Compound

Activating Compound Comment Organism Structure
testosterone left ventricle HSL activity against triglycerides is significantly elevated in intact rats supplemented with testosterone, testosterone replacement fully reverses this effect Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
left ventricle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoyl-sn-glycerol + H2O
-
 Rattus norvegicus 2-oleoylglycerol + oleate
-
 ?
triolein + H2O
-
 Rattus norvegicus diolein + oleate
-
 ?

Synonyms

Synonyms Comment Organism
HSL
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function hormone-sensitive lipase regulates triglycerides breakdown under hormonal control. Left ventricle HSL activity against triglycerides is significantly elevated in intact rats supplemented with testosterone Rattus norvegicus