Any feedback?
Literature summary for 3.1.1.79 extracted from
- Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones (1988), Biochim. Biophys. Acta, 963, 258-264.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hg2+ | 0.005 mM, approx. 50% inhibition, 0.02 mM, approx. 70% inhibition | Bos taurus |  |
| phenylmethanesulfonyl fluoride | 0.01 mM, approx. 75% inhibition, 0.01 mM, approx. 90% inhibition | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 84000 | - |
x * 84000, SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Bos taurus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| pH 5.0, DE-52, hydroxyapatite | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | cotyledon | Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.3 | - |
hydrolysis of estradiol-17-beta-oleate | Bos taurus |
| 2.6 | - |
hydrolysis of 1-oleoyl-2-oleylglycerol | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dioleoyl-sn-glycerol + H2O | - |
Bos taurus | 2-oleylglycerol + oleate | - |
? | |
| cholesteryl oleate + H2O | 18.5% of activity with 1-oleoyl-2-oleylglycerol | Bos taurus | cholesterol + oleate | - |
? | |
| dehydroepiandrosterone oleate + H2O | 12.9% of activity with 1-oleoyl-2-oleylglycerol | Bos taurus | dehydroepiandrosterone + oleate | - |
? | |
| estradiol-17-beta-oleate + H2O | 17.9% of activity with 1-oleoyl-2-oleylglycerol | Bos taurus | 17-beta-estradiol + oleate | - |
? | |
| estradiol-17-beta-palmitate + H2O | 18.3% of activity with 1-oleoyl-2-oleylglycerol | Bos taurus | 17-beta-estradiol + palmitate | - |
? | |
| testosterone oleate + H2O | 1.4% of activity with 1-oleoyl-2-oleylglycerol | Bos taurus | testosterone + oleate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 84000, SDS-PAGE | Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
