A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase

Staab, J.F.; Ginkel, D.L.; Rosenberg, G.B.; Munford, R.S.; J. Biol. Chem. 269, 23736-23742 (1994)

Data extracted from this reference:

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

3-(acyloxy)acyl group of bacterial toxin

Homo sapiens

detoxification of LPS

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

Homo sapiens

-

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

3-(acyloxy)acyl group of bacterial toxin

detoxification of LPS

246552

Homo sapiens

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

246552

Homo sapiens

-

3-(acyloxy)acyl group of bacterial toxin + H2O

-

246552

Homo sapiens

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

246552

Homo sapiens

?

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

3-(acyloxy)acyl group of bacterial toxin

Homo sapiens

detoxification of LPS

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

Homo sapiens

-

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

3-(acyloxy)acyl group of bacterial toxin

detoxification of LPS

246552

Homo sapiens

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

246552

Homo sapiens

-

3-(acyloxy)acyl group of bacterial toxin + H2O

-

246552

Homo sapiens

3-hydroxyacyl group of bacterial toxin + a fatty acid

-

246552

Homo sapiens

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

749541

Yang

Acyloxyacyl hydrolase modulat ...

Mus musculus

Am. J. Physiol. Regul. Integr. Comp. Physiol.

314

R353-R365

2018

-

1

-

-

-

-

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4

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1

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1

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-

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-

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-

-

-

-

-

-

-

-

-

-

-

-

-

1

1

-

-

-

751999

Zou

Acyloxyacyl hydrolase promote ...

Mus musculus

PLoS Pathog.

13

e1006436

2017

-

1

-

-

-

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4

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1

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-

-

-

-

-

1

1

-

-

-

730832

Janelsins

Altered inactivation of commen ...

Mus musculus

Proc. Natl. Acad. Sci. USA

111

373-378

2014

-

-

-

-

-

-

-

-

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1

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3

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5

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1

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1

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1

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5

-

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1

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-

-

-

-

-

2

2

-

-

-

715145

Shao

Prolonged hepatomegaly in mice ...

Mus musculus

Hepatology

54

1051-1062

2011

-

-

-

-

-

-

-

-

-

-

-

-

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6

-

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1

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1

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-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

2

2

-

-

-

716472

Klaffenbach

Contribution of different plac ...

Homo sapiens

Placenta

32

830-837

2011

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

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-

-

-

3

-

-

-

-

1

-

-

-

-

-

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-

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-

-

-

-

-

-

3

-

-

-

-

-

-

-

-

-

-

-

-

2

1

1

2

-

-

704964

Ojogun

Overproduction of acyloxyacyl ...

Mus musculus

J. Infect. Dis.

200

1685-1693

2009

-

1

-

-

-

-

-

-

-

-

-

-

-

5

-

-

-

-

-

1

-

-

1

-

1

-

-

-

-

1

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

1

-

-

-

-

1

1

-

-

-

691683

Lu

Host inactivation of bacterial ...

Mus musculus

Cell host microbe

4

293-302

2008

-

-

-

-

1

-

-

-

-

-

-

-

-

4

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

680766

Shao

A host lipase detoxifies bacte ...

Mus musculus

J. Biol. Chem.

282

13726-13735

2007

-

-

-

-

-

-

-

-

-

-

-

1

-

3

-

-

-

-

-

1

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

680889

Gioannini

Endotoxin-binding proteins mod ...

Homo sapiens

J. Biol. Chem.

282

7877-7884

2007

-

-

-

-

-

-

-

-

-

-

-

1

-

2

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

682968

Mehrzad

Bovine blood neutrophil acylox ...

Bos taurus

Vet. Res.

38

655-668

2007

-

-

-

-

-

-

-

-

-

-

-

1

-

3

-

-

-

-

-

3

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

3

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

680332

Barnes

Polymorphisms in the novel gen ...

Homo sapiens

J. Allergy Clin. Immunol.

118

70-77

2006

-

-

-

-

-

-

-

-

-

-

-

1

-

1

-

-

-

-

-

-

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

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-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

665166

feulner

Identification of acyloxyacyl ...

Mus musculus

Infect. Immun.

72

3171-3178

2004

-

-

-

-

-

-

-

-

-

-

-

1

-

3

-

1

-

-

-

7

-

-

2

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

1

-

-

7

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

665875

Lu

Stimulus-dependent deacylation ...

Mus musculus

J. EXp. Med.

197

1745-1754

2003

-

-

-

-

-

-

-

-

-

-

-

1

-

3

-

-

-

-

-

1

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

246554

Staab

-

Distinctive structural feature ...

Homo sapiens, Mus musculus, Oryctolagus cuniculus

J. Endotoxin Res.

5

205-208

1999

-

-

3

-

-

-

-

3

-

-

-

3

-

3

-

3

-

-

-

-

-

-

6

3

-

-

-

-

-

-

-

-

-

-

-

-

-

-

3

-

-

-

-

-

-

-

3

-

-

-

3

-

-

3

-

-

-

-

-

6

3

-

-

-

-

-

-

-

-

-

-

-

-

-

-

246553

Cody

-

Effect of inflammatory and ant ...

Mus musculus

J. Endotoxin Res.

4

371-379

1997

-

-

-

-

-

-

-

-

-

-

-

1

-

1

-

-

-

-

-

1

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

1

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

246552

Staab

A saposin-like domain influenc ...

Homo sapiens

J. Biol. Chem.

269

23736-23742

1994

-

-

-

-

-

-

-

-

1

-

3

1

-

2

-

1

1

-

-

-

-

-

2

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

3

1

-

-

1

1

-

-

-

-

2

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

246547

Munford

Acyloxyacyl hydrolase, a leuko ...

Homo sapiens

J. Biol. Chem.

267

10116-10121

1992

2

-

-

-

-

-

3

2

-

-

-

1

-

2

-

-

1

-

-

2

-

-

8

-

-

-

-

-

-

-

1

-

-

-

-

-

2

-

-

-

-

-

-

-

3

-

2

-

-

-

1

-

-

-

1

-

2

-

-

8

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

246551

Munford

Eukaryotic lipopolysaccharide ...

Homo sapiens

Methods Enzymol.

209

485-492

1992

1

-

1

-

-

-

-

-

-

1

-

1

-

1

-

-

1

-

-

-

2

-

2

-

-

-

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-

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-

-

-

-

-

-

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1

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1

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1

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1

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1

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2

-

2

-

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-

-

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-

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-

-

-

246546

Hagen

Expression and characterizatio ...

Homo sapiens

Biochemistry

30

8415-8423

1991

-

-

1

-

-

-

-

-

-

-

4

1

-

2

-

1

-

-

-

2

-

-

2

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

4

1

-

-

1

-

-

2

-

-

2

1

-

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-

-

-

-

-

-

-

-

-

246550

Mc Dermott

-

Intracellular and extracellula ...

Bos taurus, Homo sapiens

Infect. Immun.

59

487-485

1991

-

-

-

-

-

-

-

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-

-

-

2

-

2

-

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-

2

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-

4

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1

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-

2

-

-

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-

-

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-

-

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-

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2

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2

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4

-

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1

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2

-

-

-

-

-

-

-

-

246545

Erwin

Deacylation of structurally di ...

Homo sapiens

J. Biol. Chem.

265

16444-16449

1990

1

1

-

-

-

-

-

3

-

1

-

1

-

8

-

-

1

-

-

2

-

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2

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-

1

1

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3

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1

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1

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1

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2

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2

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-

-

-

-

-

-

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-

246549

Munford

Purification of acyloxyacyl hy ...

Homo sapiens

J. Biol. Chem.

264

15613-15619

1989

1

-

-

-

-

-

1

1

1

-

4

1

-

3

-

1

1

-

-

1

2

-

2

1

-

-

-

-

-

1

-

-

-

-

-

-

1

-

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-

-

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-

-

1

-

1

1

-

4

1

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-

1

1

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1

2

-

2

1

-

-

-

-

1

-

-

-

-

-

-

-

-

-

246548

Munford

Detoxification of bacterial li ...

Homo sapiens

Science

234

203-205

1986

-

-

-

-

-

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-

-

-

-

-

1

-

1

-

-

-

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-

1

-

-

2

-

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1

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1

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2

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