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Literature summary for 3.1.1.7 extracted from
- Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos (2018), J. Environ. Sci. Health B, 53, 191-198 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetylthiocholine | the enzyme AChE is inhibited by high concentrations of substrate | Bos taurus |  |
| chlorpyrifos | an anti-cholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos, applied by pour-on according to the manufacturer's instructions, does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | Bos taurus | - |
thiocholine + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | P23795 | Aberdeen Angus beef cattle and crossbred steers, meat steers | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Bos taurus | thiocholine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetylcholinesterase | - |
Bos taurus |
| AChE | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Bos taurus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | acetylcholinesterase (AChE) is mainly present in erythrocytes, typically hydrolyzes acetylthiocholine (ATC) and is inhibited by excessive substrate. In cattle, 90% of cholinesterase enzyme activity is represented by AChE in erythrocytes with very low plasma BChE values | Bos taurus |
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Release 2023.1 (January 2023)
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