Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Albendin, G.; Arellano, J.M.; Manuel-Vez, M.P.; Sarasquete, C.; Arufe, M.I.
    Characterization and in vitro sensitivity of cholinesterases of gilthead seabream (Sparus aurata) to organophosphate pesticides (2017), Fish Physiol. Biochem., 43, 455-464 .
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide i.e. BW284c51, shows inhibition at high substrate concentrations Sparus aurata
azinphosmethyl-oxon
-
 Sparus aurata
dichlorvos
-
 Sparus aurata
additional information in vitro sensitivity of cholinesterases from gilthead seabream (Sparus aurata) to organophosphate pesticides (OPs), overview. The inhibitory potency of OPs on brain and muscle AChEs based on bimolecular inhibition constants (ki) is in ascending order: omethoate, dichlorvos, azinphosmethyl-oxon Sparus aurata
omethoate
-
 Sparus aurata

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics Sparus aurata
0.16
-
 acetylthiocholine pH 7.4, 25°C, enzyme from brain Sparus aurata
0.24
-
 acetylthiocholine pH 7.4, 25°C, enzyme from muscle Sparus aurata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Sparus aurata
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Sparus aurata
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sparus aurata
-
additional information AChE is the enzyme present in the brain, whereas in muscle, a typical AChE form is present along with an atypical form of butyrylcholinesterase (BChE, EC 3.1.1.8) Sparus aurata
-
muscle
-
 Sparus aurata
-
plasma cell low enzyme level Sparus aurata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Sparus aurata choline + acetate
-
 ?
acetylthiocholine + H2O i.e. acetyl-beta-(methyl)thiocholine iodide (AbMSCh) as substrate Sparus aurata thiocholine + acetate
-
 ?
additional information no activity with butyrylthiocholine Sparus aurata ?
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Sparus aurata

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Sparus aurata

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Sparus aurata