Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,4-difluoro-8-(propan-2-yl)-N-(2,3,4-trifluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
4,4-difluoro-8-(propan-2-yl)-N-propyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
4,4-difluoro-N,8-di(propan-2-yl)-1,3,4,5-tetrahydro-2Hpyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
4,4-difluoro-N-(2-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
4,4-difluoro-N-(3-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
4,4-difluoro-N-(4-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
donepezil | - |
Rattus norvegicus | |
additional information | synthesis of difluoropyrido[4,3-b]indoles and evaluation as acetylcholinesterase inhibitors, anti-amnesic effect of synthesized compounds against scopolamine-induced memory loss, overview | Rattus norvegicus | |
N-(2,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2,5-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2,6-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2-cyanophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(2-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3,5-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3-ethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(3-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(4-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-(4-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-cyclopentyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
N-ethyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | - |
Rattus norvegicus | |
neostigmine | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Rattus norvegicus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Rattus norvegicus | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Rattus norvegicus | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000067 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | donepezil | |
0.0000462 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | neostigmine | |
0.0000476 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-8-(propan-2-yl)-N-(2,3,4-trifluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000483 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2,6-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000494 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2,5-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000499 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000508 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000515 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-N-(4-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000527 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-N-(3-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000563 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-N-(2-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000653 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2-cyanophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000967 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-8-(propan-2-yl)-N-propyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000987 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0000991 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-cyclopentyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001014 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-ethyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001023 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(4-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001024 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-ethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001039 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001039 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(4-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001052 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | 4,4-difluoro-N,8-di(propan-2-yl)-1,3,4,5-tetrahydro-2Hpyrido[4,3-b]indole-2-carboxamide | |
0.0001156 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001682 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001684 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,5-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001686 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001739 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(2-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide | |
0.0001739 | - |
pH 7.4, temperature not specified in the publication | Rattus norvegicus | N-(3,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide |