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Literature summary for 3.1.1.7 extracted from
- Kinetic and physicochemical properties of brain acetylcholinesterase from the peacock bass (Cichla ocellaris) and in vitro effect of pesticides and metal ions (2013), Aquat. Toxicol., 126, 191-197.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| As3+ | - |
Cichla ocellaris |  |
| BW284C5 | i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide, complete inhibition at 1 mM | Cichla ocellaris | |
| carbofuran | - |
Cichla ocellaris | |
| Cd2+ | - |
Cichla ocellaris | |
| chlorpyrifos | - |
Cichla ocellaris | |
| Cu2+ | - |
Cichla ocellaris | |
| diazinon | - |
Cichla ocellaris | |
| dichlorvos | - |
Cichla ocellaris | |
| eserine | less than 10% residual activity ar 10 mM | Cichla ocellaris | |
| Hg2+ | - |
Cichla ocellaris | |
| additional information | no inhibitory effect by EDTA and tetraisopropyl diphosphoramide | Cichla ocellaris | |
| neostigmine | almost complete inhibition at 0.1 mM | Cichla ocellaris | |
| temephos | - |
Cichla ocellaris | |
| tetraethyl diphosphate | - |
Cichla ocellaris | |
| Zn2+ | - |
Cichla ocellaris | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.769 | - |
Acetylcholine | at pH 7.4 and 25°C | Cichla ocellaris | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Cichla ocellaris | - |
choline + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cichla ocellaris | - |
peacock bass | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cichla ocellaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Cichla ocellaris | choline + acetate | - |
? | |
| acetylthiocholine iodide + H2O | - |
Cichla ocellaris | thiocholine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Cichla ocellaris |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Cichla ocellaris |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 50 | the enzyme retains approximately 45% activity after incubation at 50°C for 30 min and 15 min equilibration at 25°C | Cichla ocellaris |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Cichla ocellaris |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00059 | - |
As3+ | at pH 7.4 and 25°C | Cichla ocellaris | |
| 0.00134 | - |
Hg2+ | at pH 7.4 and 25°C | Cichla ocellaris | |
| 0.0125 | - |
Cu2+ | at pH 7.4 and 25°C | Cichla ocellaris | |
| 0.0153 | - |
Zn2+ | at pH 7.4 and 25°C | Cichla ocellaris | |
| 0.0364 | - |
Cd2+ | at pH 7.4 and 25°C | Cichla ocellaris | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
at pH 7.4 and 25°C | Cichla ocellaris | As3+ | |
| 0.22 | - |
at pH 7.4 and 25°C | Cichla ocellaris | Hg2+ | |
| 2.1 | - |
at pH 7.4 and 25°C | Cichla ocellaris | Cu2+ | |
| 2.57 | - |
at pH 7.4 and 25°C | Cichla ocellaris | Zn2+ | |
| 6.14 | - |
at pH 7.4 and 25°C | Cichla ocellaris | Cd2+ | |
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