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Literature summary for 3.1.1.7 extracted from

  • Lee, Y.K.; Yuk, D.Y.; Kim, T.I.; Kim, Y.H.; Kim, K.T.; Kim, K.H.; Lee, B.J.; Nam, S.Y.; Hong, J.T.
    Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity (2009), J. Nat. Med., 63, 274-282.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
Scopolamine induces and increase of AChE activity in the cortex and hippocampus of mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-O-methylhonokiol isolated from ethanol extract of Magnolia officinalis. 4-O-methylhonokiol also dose-dependently attenuates the scopolamine-induced increase of AChE activity in the cortex and hippocampus of mice Mus musculus
additional information inhibitory effect on AChE of the ethanol extract of Magnolia officinalis, overview Mus musculus
tacrine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Mus musculus
-
 acetate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male ICR mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain cortex
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Mus musculus acetate + choline
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000012
-
 pH 7.4, 25°C Mus musculus 4-O-methylhonokiol
0.000135
-
 pH 7.4, 25°C Mus musculus tacrine