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Literature summary for 3.1.1.7 extracted from

  • Kakinuma, Y.; Furihata, M.; Akiyama, T.; Arikawa, M.; Handa, T.; Katare, R.G.; Sato, T.
    Donepezil, an acetylcholinesterase inhibitor against Alzheimers dementia, promotes angiogenesis in an ischemic hindlimb model (2010), J. Mol. Cell. Cardiol., 48, 680-693.
    View publication on PubMed
Search for more literature for 3.1.1.7

Protein Variants

Protein Variants Comment Organism
additional information donepezil accelerates angiogenesis even in alpha7 KO mice with hindlimb ischemia. alpha7 KO mice phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
donepezil besides inhibiting the acetylcholinesterase donepezil can act as a therapeutic tool to accelerate angiogenesis in cardiovascular disease patients, overview Homo sapiens
donepezil donepezil concomitantly elevates VEGF expression in intracardiac endothelial cells of wild-type and alpha7 KO mice and further increases choline acetyltransferase protein expression, which is critical for acetylcholine synthesis in endothelial cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Mus musculus acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion acetate + choline
-
 ?
acetylcholine + H2O Homo sapiens acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion acetate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male C57BL6/J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell HUVECs Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Mus musculus acetate + choline
-
 ?
acetylcholine + H2O
-
 Homo sapiens acetate + choline
-
 ?
acetylcholine + H2O acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion Mus musculus acetate + choline
-
 ?
acetylcholine + H2O acetylcholine protects cardiomyocytes from prolonged hypoxia through activation of the PI3K/Akt/HIF-1alpha/VEGF pathway and that cardiomyocyte-derived VEGF promotes angiogenesis in a paracrine fashion Homo sapiens acetate + choline
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Mus musculus
AChE
-
 Homo sapiens