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Literature summary for 3.1.1.7 extracted from

  • Shen, Y.; Zhang, J.; Sheng, R.; Dong, X.; He, Q.; Yang, B.; Hu, Y.
    Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors (2009), J. Enzyme Inhib. Med. Chem., 24, 372-380.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
(E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
(E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
 Rattus norvegicus
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
 Rattus norvegicus
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
 Rattus norvegicus
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
 Rattus norvegicus
3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
 Rattus norvegicus
3-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
 Rattus norvegicus
3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
 Rattus norvegicus
4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
 Rattus norvegicus
4-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
 Rattus norvegicus
additional information molecular modelling and inhibitor docking, overview. No inhibition by 3-(1-benzylpiperidin-4-yloxy)benzaldehyde, 3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde, 4-(1-benzylpiperidin-4-yloxy)benzaldehyde, {(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one, and (E)-3-(3-((1-benzylpiperidin-4-yl)nethoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Rattus norvegicus
-
 acetate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Rattus norvegicus acetate + choline
-
 ?
acetylthiocholine iodide + H2O
-
 Rattus norvegicus acetate + thiocholine iodide
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000093
-
 pH 7.4, 37°C Rattus norvegicus 3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.00072
-
 pH 7.4, 37°C Rattus norvegicus 3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.00129
-
 pH 7.4, 37°C Rattus norvegicus 3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.00163
-
 pH 7.4, 37°C Rattus norvegicus 3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.0041
-
 pH 7.4, 37°C Rattus norvegicus 2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.0066
-
 pH 7.4, 37°C Rattus norvegicus 2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.0076
-
 pH 7.4, 37°C Rattus norvegicus 2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
0.0086
-
 pH 7.4, 37°C Rattus norvegicus 2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.011
-
-
 Rattus norvegicus 2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
0.0127
-
 pH 7.4, 37°C Rattus norvegicus 2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
0.0137
-
 pH 7.4, 37°C Rattus norvegicus 2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
0.0204
-
 pH 7.4, 37°C Rattus norvegicus (E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
0.0242
-
 pH 7.4, 37°C Rattus norvegicus (E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
0.0304
-
 pH 7.4, 37°C Rattus norvegicus 2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
0.0566
-
 pH 7.4, 37°C Rattus norvegicus 4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde