Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-(+)-endo-2-norbornyl-N-n-butylcarbamate | synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer | Electrophorus electricus | |
(R)-(+)-exo-2-norbornyl-N-n-butylcarbamate | synthesis of enantiomers for stereoselective inhibition of AChE, overview. The R-enantiomer is potent, while the S-enantiomer is inactive | Electrophorus electricus | |
(S)-(-)-endo-2-norbornyl-N-n-butylcarbamate | synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer | Electrophorus electricus | |
Carbaryl | - |
Electrophorus electricus | |
additional information | no inhibition by (S)-(-)-exo-2-norbornyl-N-n-butylcarbamate at 0.01 mM. Optically pure2-norbornyl-N-n-butylcarbamate enantiomers are synthesized from condensations of optically pure (R)-(1)-exo-, (S)-(2)-exo-, (R)-(1)-endo-, and (S)-(2)-endo-2-norborneols with n-butyl isocyanate, respectively. Molecular modeling, overview | Electrophorus electricus | |
physostigmine | - |
Electrophorus electricus | |
rivastigmine | - |
Electrophorus electricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Electrophorus electricus | - |
acetate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetylcholine + H2O = choline + acetate | the mechanism for AChE-catalyzed hydrolysis of substrate is formation of the first tetrahedral intermediate via nucleophilic attack of the active site serine | Electrophorus electricus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Electrophorus electricus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Electrophorus electricus | acetate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Electrophorus electricus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Electrophorus electricus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
pH 7.0, 25°C | Electrophorus electricus | (S)-(-)-endo-2-norbornyl-N-n-butylcarbamate | |
0.000056 | - |
pH 7.0, 25°C | Electrophorus electricus | (R)-(+)-exo-2-norbornyl-N-n-butylcarbamate | |
0.00008 | - |
pH 7.0, 25°C | Electrophorus electricus | (R)-(+)-endo-2-norbornyl-N-n-butylcarbamate |