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Literature summary for 3.1.1.7 extracted from

  • Huang, L.; Shi, A.; He, F.; Li, X.
    Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors (2010), Bioorg. Med. Chem., 18, 1244-1251.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
-
Electrophorus electricus
9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
-
Electrophorus electricus
9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
-
Electrophorus electricus
9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
-
Electrophorus electricus
9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
-
Electrophorus electricus
9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
-
Electrophorus electricus
9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
-
Electrophorus electricus
9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
Electrophorus electricus
9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
-
Electrophorus electricus
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide most potent berberine derivative inhibitor, mixed type inhibition Electrophorus electricus
9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
Electrophorus electricus
9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
-
Electrophorus electricus
9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
-
Electrophorus electricus
9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
Electrophorus electricus
9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
-
Electrophorus electricus
Berberine competitive inhibition Electrophorus electricus
donepezil
-
Electrophorus electricus
galanthamine
-
Electrophorus electricus
huperzine A
-
Electrophorus electricus
additional information synthesis and biological evaluation of berberine derivatives as potent acetylcholinesterase inhibitors, kinetic and molecular modeling studies, overview Electrophorus electricus
tacrine
-
Electrophorus electricus

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine chloride + H2O
-
Electrophorus electricus acetate + choline chloride
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
in vitro assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
in vitro assay at Electrophorus electricus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000045
-
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide pH 8.0, 37°C Electrophorus electricus
0.000289
-
Berberine pH 8.0, 37°C Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000052
-
pH 8.0, 37°C Electrophorus electricus 9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
0.000097
-
pH 8.0, 37°C Electrophorus electricus 9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide
0.000123
-
pH 8.0, 37°C Electrophorus electricus 9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
0.000224
-
pH 8.0, 37°C Electrophorus electricus 9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
0.000224
-
pH 8.0, 37°C Electrophorus electricus 9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
0.00028
-
pH 8.0, 37°C Electrophorus electricus 9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
0.000359
-
pH 8.0, 37°C Electrophorus electricus 9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
0.000374
-
pH 8.0, 37°C Electrophorus electricus Berberine
0.000375
-
pH 8.0, 37°C Electrophorus electricus 9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
0.000398
-
pH 8.0, 37°C Electrophorus electricus 9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
0.000515
-
pH 8.0, 37°C Electrophorus electricus 9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
0.000623
-
pH 8.0, 37°C Electrophorus electricus galanthamine
0.000856
-
pH 8.0, 37°C Electrophorus electricus 9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
0.00112
-
pH 8.0, 37°C Electrophorus electricus 9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
0.00123
-
pH 8.0, 37°C Electrophorus electricus 9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
0.00168
-
pH 8.0, 37°C Electrophorus electricus 9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
0.0021
-
pH 8.0, 37°C Electrophorus electricus 9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide