Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine | - |
Rattus norvegicus | |
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine | - |
Rattus norvegicus | |
galanthamine | - |
Rattus norvegicus | |
additional information | design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors, overview | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Rattus norvegicus | acetate + thiocholine iodide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000056 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.0000065 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine | |
0.0000089 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine | |
0.0000124 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine | |
0.000018 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine | |
0.0000245 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine | |
0.0000347 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine | |
0.0000538 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine | |
0.0000581 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine | |
0.0000612 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine | |
0.0000881 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine | |
0.0000941 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine | |
0.0000991 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine | |
0.000113 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.000122 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine | |
0.000146 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine | |
0.000154 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine | |
0.000222 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine | |
0.000306 | - |
pH 7.4, 37°C | Rattus norvegicus | 10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine | |
0.001165 | - |
pH 7.4, 37°C | Rattus norvegicus | galanthamine |