Literature summary for 3.1.1.7 extracted from

Lee, S.H.; Park, J.S.; Kim, S.K.; Ahn, C.B.; Je, J.Y.
Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells (2009), Bioorg. Med. Chem. Lett., 19, 860-862.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	beta-amyloid peptides Abeta25-35 induce AChE protein expression in PC12 cell lines	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
chitooligosaccharides	90-COSs and 50-COSs are prepared from 90% and 50% deacetylated chitosan, cellular AChE activity is decreased with increasing concentration of 90-MMWCOS chitooligosaccharides in PC12 cell lines, the 90-COSs exhibit more potent AChE inhibitory activities compared to 50-COSs, while 90-MMWCOS, 1-5 kDa, in the 90COSs show the highest activity, overview	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Rattus norvegicus

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Release 2023.1 (January 2023)