Literature summary for 3.1.1.7 extracted from

Pastorin, G.; Marchesan, S.; Hoebeke, J.; Da Ros, T.; Ehret-Sabatier, L.; Briand, J.P.; Prato, M.; Bianco, A.
Design and activity of cationic fullerene derivatives as inhibitors of acetylcholinesterase (2006), Org. Biomol. Chem., 4, 2556-2562.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bis-N,N-dimethylfulleropyrrolidinium salts	inhibitory activity and mechanism of cationic fulleropyrrolidinium regioisomers, AChE docking parameters, molecular modleing, overview	Electrophorus electricus
edrophonium chloride	-	Electrophorus electricus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0644	0.0809	bis-N,N-dimethylfulleropyrrolidinium salts	pH 7.2	Electrophorus electricus
0.0689	-	edrophonium chloride	pH 7.2	Electrophorus electricus

Organism

Organism	UniProt	Comment	Textmining
Electrophorus electricus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Electrophorus electricus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylthiocholine + H2O	-	Electrophorus electricus	thiocholine + acetate	-	?
edrophonium chloride + H2O	-	Electrophorus electricus	?	-	?

Synonyms

Synonyms	Comment	Organism
AChE	-	Electrophorus electricus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Electrophorus electricus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0156	0.0314	bis-N,N-dimethylfulleropyrrolidinium salts	pH 7.2	Electrophorus electricus
0.054	-	edrophonium chloride	pH 7.2	Electrophorus electricus

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Release 2023.1 (January 2023)