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Literature summary for 3.1.1.7 extracted from

  • Groner, E.; Ashani, Y.; Schorer-Apelbaum, D.; Sterling, J.; Herzig, Y.; Weinstock, M.
    The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates (2007), Mol. Pharmacol., 71, 1610-1617.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
N-methyl,N-alkyl carbamates AChE inhibition is mainly determined by the size of the N-alkyl substituent and to a lesser extent by the nature of the leaving group, Ki was highest when the alkyl is methyl, hexyl, cyclohexyl, or an aromatic substituent and lowest when it is ethyl, ki depends on a delicate balance between the length of the residue and its degree of freedom of rotation, overview Homo sapiens
rivastigmine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state kinetics, recombinant enzyme, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
acetylcholine + H2O the enzyme might be involved in slowing of neurodegeneration in Alzheimer’s and Parkinson’s diseases, overview Homo sapiens choline + acetate
-
 ?
acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, recombinant enzyme, overview Homo sapiens