Cloned (Comment) | Organism |
---|---|
- |
Electrophorus electricus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(dimethylamino)-7-ethyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.011 mM | Electrophorus electricus | |
2-(dimethylamino)-7-isobutyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00036 mM | Electrophorus electricus | |
2-(dimethylamino)-7-methyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.039 mM | Electrophorus electricus | |
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.0059 mM | Electrophorus electricus | |
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one | 50% inhibition at 0.0012 mM | Electrophorus electricus | |
7-benzoyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.036 mM | Electrophorus electricus | |
7-benzyl-2-((3,4-dimethoxybenzyl)(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00033 mM | Electrophorus electricus | |
7-benzyl-2-(4-benzylpiperazin-1-yl)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00132 mM | Electrophorus electricus | |
7-benzyl-2-(benzyl(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00084 mM | Electrophorus electricus | |
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00286 mM | Electrophorus electricus | |
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one | 50% inhibition at 0.0052 mM | Electrophorus electricus | |
7-benzyl-2-(cyclohexylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one | 50% inhibition at 0.00282 mM | Electrophorus electricus | |
7-benzyl-2-(diethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00208 mM | Electrophorus electricus | |
7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00089 mM | Electrophorus electricus | |
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00074 mM | Electrophorus electricus | |
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one | 50% inhibition at 0.00058 mM | Electrophorus electricus | |
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00094 mM | Electrophorus electricus | |
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one | 50% inhibition at 0.00103 mM | Electrophorus electricus | |
7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one | 50% inhibition at 0.00077 mM | Electrophorus electricus | |
neostigmine bromide | competitive | Electrophorus electricus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
67000 | - |
gel filtration | Electrophorus electricus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | sequence contains a signal peptide | Electrophorus electricus |
Purification (Comment) | Organism |
---|---|
- |
Electrophorus electricus |
Subunits | Comment | Organism |
---|---|---|
? | enzyme exists as a mixture of 88 kDa dimers consisting of disulfide-linked 42- to 44-kDa polypeptides and a 42- to 44-kDa monomer, SDS-PAGE | Electrophorus electricus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
neostigmine bromide | pH 7.0, 30°C, substrate acetylthiocholine | Electrophorus electricus | |
0.0047 | - |
neostigmine bromide | pH 7.0, 30°C, substrate propionylthiocholine | Electrophorus electricus |