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Literature summary for 3.1.1.7 extracted from
- Acetylcholinesterase at high catalytic efficiency and substrate specificity in the optic lobe of Eledone moschata (Cephalopoda: Octopoda): biochemical characterization and histochemical localization (1998), Neurochem. Int., 33, 131-141.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BW4c51 | - |
Eledone moschata |  |
| diisopropylfluorophosphate | - |
Eledone moschata | |
| edrophonium | - |
Eledone moschata | |
| physostigmine | - |
Eledone moschata | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
propionylthiocholine | form II | Eledone moschata | |
| 0.398 | - |
propionylthiocholine | form I | Eledone moschata | |
| 0.72 | - |
acetylthiocholine | form II | Eledone moschata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
2 * 66000, SDS-PAGE | Eledone moschata |
| 135000 | 136000 | gel filtration | Eledone moschata |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Eledone moschata | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Eledone moschata | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| forms I and II | Eledone moschata |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| optic lobe | - |
Eledone moschata | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 700 | - |
- |
Eledone moschata |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Eledone moschata | choline + acetate | - |
? | |
| acetylcholine + H2O | - |
Eledone moschata | ? | - |
? | |
| acetylthiocholine + H2O | - |
Eledone moschata | thiocholine + acetate | - |
? | |
| butyrylthiocholine + H2O | - |
Eledone moschata | butyrate + thiocholine | - |
? | |
| propionylthiocholine + H2O | - |
Eledone moschata | propanoate + thiocholine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 66000, SDS-PAGE | Eledone moschata |
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