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Literature summary for 3.1.1.67 extracted from

  • Bora, P.S.; Miller, D.D.; Chaitman, B.R.
    Mutagenesis and characterization of specific residues in fatty acid ethyl ester synthase: A gene for alcohol-induced cardiomyopathy (1998), Mol. Cell. Biochem., 180, 111-115.
    View publication on PubMed
Search for more literature for 3.1.1.67

Cloned(Commentary)

Cloned (Comment) Organism
native and mutant forms of FAEES-III cDNA are cloned and expressed in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C39W mutation does not affect FAEES activity Homo sapiens
G32Q mutation does not affect FAEES activity Homo sapiens
H72S mutation does not affect FAEES activity, less than 9% of control glutathione S-transferase activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 x * 26000, FAEES-III, immunoblot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FAEES-III metabolizes both ethanol and carcinogens ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 FAEES-III
-

Reaction

Reaction Comment Organism Reaction ID
a long-chain-fatty-acyl ethyl ester + H2O = a long-chain-fatty acid + ethanol mechanism Homo sapiens
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0006
-
 native FAEES-III and mutants G32Q, C39W, H72S Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fatty acid + ethanol
-
 Homo sapiens fatty acyl ethyl ester + H2O
-
 ?
additional information FAEES-III also catalyzes the glutathione S-transferase reaction Homo sapiens ?
-
 ?
additional information FAEES-III metabolizes both ethanol and carcinogens Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 26000, FAEES-III, immunoblot analysis Homo sapiens