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Literature summary for 3.1.1.64 extracted from

  • Kolesnikov, A.; Tang, P.; Kefalov, V.
    Examining the role of cone-expressed RPE65 in mouse cone function (2018), Sci. Rep., 8, 14201 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16518
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Mus musculus Q91ZQ5
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Source Tissue

Source Tissue Comment Organism Textmining
cone
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Mus musculus
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cone
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Homo sapiens
-

General Information

General Information Comment Organism
physiological function deletion of RPE65 partially suppresses cone dark adaptation. Transgenic mice expressing human RPE65 in the cones reveal no morphological or functional changes between control (RPE65-deficient) and transgenic cones, with only a slight delay in dark adaptation, possibly caused by the buffering of retinoids by RPE65 Mus musculus
physiological function transgenic mice expressing human RPE65 in the cones reveal no morphological or functional changes between control (RPE65-deficient) and transgenic cones, with only a slight delay in dark adaptation, possibly caused by the buffering of retinoids by RPE65 Homo sapiens