Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.64 extracted from

  • Poliakov, E.; Gubin, A.N.; Stearn, O.; Li, Y.; Campos, M.M.; Gentleman, S.; Rogozin, I.B.; Redmond, T.M.
    Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates (2012), PLoS ONE, 7, e49975.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.64

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid seuence determination and analysis, phylogenetic analyis and tree, and sequence comparisons, expression in HEK293-F cells Petromyzon marinus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an all-trans-retinyl ester + H2O Petromyzon marinus
-
 11-cis-retinol + a fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
no activity in cephalochordata
-
-
-
no activity in tunicata
-
-
-
Petromyzon marinus L0ATZ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Petromyzon marinus
-
retina
-
 Petromyzon marinus
-
retinal pigment epithelium
-
 Petromyzon marinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an all-trans-retinyl ester + H2O
-
 Petromyzon marinus 11-cis-retinol + a fatty acid
-
 ?
an all-trans-retinyl ester + H2O the enzyme generates 11-cis-retinol and 13-cis-retinol from all-trans-retinyl ester Petromyzon marinus 11-cis-retinol + a fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
isomerohydrolase
-
 Petromyzon marinus
Rpe65
-
 Petromyzon marinus

General Information

General Information Comment Organism
evolution the enzyme belongs to the RPE65/BCMO Superfamily. The crucial transition from the typical carotenoid double bond cleavage functionality to the isomerohydrolase functionality (RPE65), coupled with the origin of lecithin:retinol acyltransferase, occurred subsequent to divergence of the more primitive chordates (tunicates, etc.) in the last common ancestor of the jawless and jawed vertebrates Petromyzon marinus