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Literature summary for 3.1.1.64 extracted from

  • Lopes, V.S.; Gibbs, D.; Libby, R.T.; Aleman, T.S.; Welch, D.L.; Lillo, C.; Jacobson, S.G.; Radu, R.A.; Steel, K.P.; Williams, D.S.
    The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 (2011), Hum. Mol. Genet., 20, 2560-2570.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
MYO7A protein the Usher 1B protein MYO7A is required for normal localization and function of the visual retinoid cycle enzyme RPE65. RPE65 normally undergoes a light-dependent translocation to become more concentrated in the central region of the RPE cells. This translocation requires MYO7A Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information in the dark, RPE65 is distributed more extensively throughout the cell, but upon exposure to light (about 100 lux, 2 h), it becomes concentrated more in the central region Mus musculus
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelium cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
RPE isomerase
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 Mus musculus
Rpe65
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus Myo7a-mutant mice have lower levels of RPE65 down
Mus musculus 2 h exposure to light effects a 25% increase over dark-adapted RPE65 levels in wild type retinas up