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Literature summary for 3.1.1.64 extracted from

  • Takahashi, Y.; Moiseyev, G.; Chen, Y.; Farjo, K.; Nikolaeva, O.; Ma, J.X.
    An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain (2011), FEBS J., 278, 973-987.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in 293A-lecithin retinol acyltransferase cells Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
bipyridine the addition of 6 mM FeSO4 into the iron chelator reaction restores partial enzyme activity Danio rerio

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
an all-trans retinyl ester pH and temperature not specified in the publication Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Danio rerio 5829
-
membrane
-
Danio rerio 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ enzymatic activity is dependent on iron Danio rerio

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
x * 61000, estimated from SDS-PAGE Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio A9C3R9
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA resin column chromatography Danio rerio

Source Tissue

Source Tissue Comment Organism Textmining
brain 13cIMH expression is detected in the periventricular grey zone of the optic tectum and torus longitudinalis, at the fasciculus longitudinalis medialis in the medulla oblongata, and at the periventricular pretectum Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an all-trans retinyl ester + H2O specific substrate Danio rerio 13-cis-retinol + a fatty acid
-
?

Subunits

Subunits Comment Organism
? x * 61000, estimated from SDS-PAGE Danio rerio

Synonyms

Synonyms Comment Organism
13-cis isomerohydrolase
-
Danio rerio
13cIMH
-
Danio rerio

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00044
-
an all-trans retinyl ester pH and temperature not specified in the publication Danio rerio

General Information

General Information Comment Organism
physiological function 13cIMH may play a key role in the modulation of neuronal functions in the brain Danio rerio