Cloned (Comment) | Organism |
---|---|
expressed in 293A cells | Danio rerio |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bipyridine | in the presence of 1 mM of the metal chelator bipyridine the enzymatic activity of isoform RPE65c is almost completely abolished | Danio rerio |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Danio rerio | 5829 | - |
membrane | - |
Danio rerio | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | isoform RPE65a requires iron for its enzymatic activity | Danio rerio | |
Fe2+ | isoform RPE65c requires iron for its enzymatic activity | Danio rerio |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | A9C3R8 | isoform RPE65c | - |
Danio rerio | Q6PBW5 | isoform RPE65a | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | isoform RPE65c is not detected in the retinal pigment epithelium | Danio rerio | - |
Mueller cell | - |
Danio rerio | - |
retina | - |
Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 all-trans-retinyl ester + 2 H2O | intrinsic substrate for isoform RPE65c | Danio rerio | 11-cis-retinol + 13-cis-retinol + 2 a fatty acid | - |
? | |
all-trans-retinyl ester + H2O | - |
Danio rerio | 11-cis-retinol + a fatty acid | - |
? | |
additional information | isoform RPE65c does not generate any detectable 11-cis-retinol from all-trans-retinol | Danio rerio | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RPE65a | isoform | Danio rerio |
RPE65c | isoform | Danio rerio |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform RPE65c is the alternative isomerohydrolase in the intra-retinal visual cycle, providing 11-cis retinal to cone photoreceptors in cone-dominant species | Danio rerio |