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Literature summary for 3.1.1.64 extracted from

  • Poliakov, E.; Parikh, T.; Ayele, M.; Kuo, S.; Chander, P.; Gentleman, S.; Redmond, T.M.
    Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity (2011), Biochemistry, 50, 6739-6741.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.64

Inhibitors

Inhibitors Comment Organism Structure
2,2-dimethyl-4-phenyl-2H-imidazole-1-oxide strong inhibition of isomerohydrolase activity (32% at 0.2 mM) in vitro Bos taurus
2-(2-carboxyethyl)-2-methyl-4-phenyl-2H-imidazole-1-oxide moderate inhibitory effect at 0.2 mM Bos taurus
additional information not inhibited by N-tert-butyl-(2-sulfophenyl)nitrone, alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone, NXY059, tert-butylhydroxylamine, and 2-methyl-2-nitrosopropane Bos taurus
n-benzylidene-tert-butylamine 14% inhibition at 0.2 mM Bos taurus
N-tert-butyl-alpha-phenylnitrone strong uncompetitive inhibition (52%) of isomerohydrolase activity in vitro at 0.2 mM Bos taurus
nitrosobenzene strong inhibition of isomerohydrolase activity in vitro at 0.2 mM Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelial cell
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinyl ester + H2O
-
 Bos taurus 11-cis-retinol + a fatty acid RPE65 does not specifically produce 11-cis-retinol only but also 13-cis-retinol ?

Synonyms

Synonyms Comment Organism
Rpe65
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.061
-
 N-tert-butyl-alpha-phenylnitrone pH and temperature not specified in the publication Bos taurus