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Literature summary for 3.1.1.64 extracted from

  • Redmond, T.M.; Poliakov, E.; Kuo, S.; Chander, P.; Gentleman, S.
    RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization (2010), J. Biol. Chem., 285, 1919-1927.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F61L the mutant shows 1.02% activity compared to the wild type enzyme Homo sapiens
F61W the mutant shows 1.28% activity compared to the wild type enzyme Homo sapiens
F61Y the mutant shows 7.57% activity compared to the wild type enzyme Homo sapiens
T147A the mutant shows 12.63% activity compared to the wild type enzyme Homo sapiens
T147C the mutant shows 20.18% activity compared to the wild type enzyme Homo sapiens
T147G the mutant shows 30.02% activity compared to the wild type enzyme Homo sapiens
T147S the mutant shows 84% activity compared to the wild type enzyme Homo sapiens
T147V inactive Homo sapiens
T147W inactive Homo sapiens
T147Y inactive Homo sapiens
W331F the mutant shows 8.34% activity compared to the wild type enzyme Homo sapiens
W331L inactive Homo sapiens
W331Q inactive Homo sapiens
W331Y the mutant shows 26.72% activity compared to the wild type enzyme Homo sapiens
Y239C inactive Homo sapiens
Y239D inactive Homo sapiens
Y239F inactive Homo sapiens
Y239L inactive Homo sapiens
Y239S inactive Homo sapiens
Y239T inactive Homo sapiens
Y239W inactive Homo sapiens
Y275F the mutant shows 14.44% activity compared to the wild type enzyme Homo sapiens
Y275I inactive Homo sapiens
Y275W inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinyl ester + H2O
-
Homo sapiens 11-cis-retinol + a fatty acid
-
?
additional information RPE65 is not inherently 11-cis-specific and can produce both 11- and 13-cis isomers Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Rpe65
-
Homo sapiens