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Literature summary for 3.1.1.5 extracted from

  • Zhou, L.; Shi, M.; Zhao, L.; Lin, Z.; Tang, Z.; Sun, H.; Chen, T.; Lv, Z.; Xu, J.; Huang, Y.; Yu, X.
    Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis (2017), Parasit. Vectors, 10, 295 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Clonorchis sinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-lysophosphatidylcholine + H2O Clonorchis sinensis
-
 glycerophosphocholine + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Clonorchis sinensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His Bind Purification Kit Clonorchis sinensis

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-lysophosphatidylcholine + H2O
-
 Clonorchis sinensis glycerophosphocholine + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
lysophospholipase A
-
 Clonorchis sinensis
lysoPLA
-
 Clonorchis sinensis

General Information

General Information Comment Organism
physiological function treating RAW264.7 cells with the enzyme significantly induces interleukin-25 expression. The enzyme activates hepatic stellate cells by upregulating interleukin-25 in macrophages through the protein kinase A-dependent B-Raf/ERK1/2 pathway and potentially promotes hepatic fibrosis during Clonorchis sinensis infection Clonorchis sinensis