General Stability | Organism |
---|---|
highly sensitive to proteolysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoate) | - |
Homo sapiens | |
diethyldicarbonate | - |
Homo sapiens | |
dithioerythritol | - |
Homo sapiens | |
NaF | - |
Homo sapiens | |
p-bromophenacyl bromide | - |
Homo sapiens | |
p-nitroguanidinobenzoate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no stimulation by Ca2+ or Mg2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 25000 + x * 31000, the 25000 Da component represents the catalytic unit, SDS-PAGE | Homo sapiens |
31000 | - |
x * 25000 + x * 31000, the 25000 Da component represents the catalytic unit, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | i.e. PAF | ? | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | the substrate mediates a wide spectrum of actions, including hypotension, changes in smooth muscle tone, vascular permeability, signalling in inflammation and allergy. The intracelluar form of the enzyme regulates the accumulation of the substrate, e.g. in macrophages and platelets | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
from erythrocytes | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.805 | - |
purified from erythrocytes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Homo sapiens | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Homo sapiens | ? | - |
? | |
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | the substrate mediates a wide spectrum of actions, including hypotension, changes in smooth muscle tone, vascular permeability, signalling in inflammation and allergy. The intracelluar form of the enzyme regulates the accumulation of the substrate, e.g. in macrophages and platelets | Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oxopentanoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-palmitoyl-sn-glycero-3-phosphocholine + 2-oxopentanoate | - |
? | |
additional information | the erythrocyte enzyme has a marked selectivity for short-chain acyl chains at sn-2 position, the linkage at the sn-1 postion may be of the ester or ether type and does not influence the catalytic effeciency | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000 + x * 31000, the 25000 Da component represents the catalytic unit, SDS-PAGE | Homo sapiens |