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Literature summary for 3.1.1.47 extracted from
- A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) (1981), J. Biol. Chem., 256, 175-178.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Alkyl-2,3-diacetyl-sn-glycerol | slight | Rattus norvegicus |  |
| 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine | - |
Rattus norvegicus | |
| 2-acetyl-1-acyl-glycero-sn-glycero-3-phosphocholine | - |
Rattus norvegicus | |
| 3-Hexadecyl-2-acetyl-sn-glycero-1-phosphocholine | - |
Rattus norvegicus | |
| deoxycholate | - |
Rattus norvegicus | |
| diisopropylfluorophosphate | - |
Rattus norvegicus | |
| phosphatidylcholine | from egg, long chain diacetyl type, slight | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0031 | - |
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no stimulation by Ca2+ or Mg2+ | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. PAF | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| plasma | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0031 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O | i.e. PAF | Rattus norvegicus | 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate | - |
? | |
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Rattus norvegicus | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | i.e. PAF | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
enzyme assay | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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