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Literature summary for 3.1.1.47 extracted from

  • Rosenson, R.S.; Vracar-Grabar, M.; Helenowski, I.
    Lipoprotein associated phospholipase A2 inhibition reduces generation of oxidized fatty acids: Lp-LPA2 reduces oxidized fatty acids (2008), Cardiovasc. Drugs Ther., 22, 55-58.
    View publication on PubMed
Search for more literature for 3.1.1.47

Application

Application Comment Organism
medicine lipoprotein associated phospholipase A2 is a cardiovascular risk marker, in addition, its inhibition reduces the generation of oxidized fatty acids Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SB-677116
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 without inhibitor SB-677116, 24.64 nmol/min per ml, 0.3 microM SB-677116 added, 2.05 nmol/min per ml, 3.0 microM SB-677116 added, 0.63 nmol/min per ml Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Lp-PLA2 generates oxidized nonesterified fatty acids and lysophosphatidylcholine, both of which have demonstrated proinflammatory and proapoptotic activities Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
lipoprotein associated phospholipase A2
-
 Homo sapiens
Lp-PLA2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 activity assay Homo sapiens