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Literature summary for 3.1.1.47 extracted from

  • Quistad, G.B.; Fisher, K.J.; Owen, S.C.; Klintenberg, R.; Casida, J.E.
    Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates (2005), Toxicol. Appl. Pharmacol., 205, 149-156.
    View publication on PubMed
Search for more literature for 3.1.1.47

Inhibitors

Inhibitors Comment Organism Structure
2-N-methylcarbamyl platelet-activating factor weak inhibition Homo sapiens
2-N-methylcarbamyl platelet-activating factor weak inhibition Mus musculus
benzodioxaphosphorin 2-oxides weak or no inhibition Homo sapiens
benzodioxaphosphorin 2-oxides decyl-derivative shows the strongest inhibition among the benzodioxaphosphorin 2-oxides tested Mus musculus
chlorpyrifos oxon ethyl- and methyl-derivative Homo sapiens
chlorpyrifos oxon pentyl- ethyl- and methyl-derivative Mus musculus
diazoxon weak inhibition Homo sapiens
diazoxon weak inhibition Mus musculus
n-alkyl methylphosphonofluoridates derivatives with chain length C13-C18 are highly potent in vitro inhibitors Homo sapiens
n-alkyl methylphosphonofluoridates derivatives with chain length C8-C18 are highly potent in vitro inhibitors Mus musculus
Sulfonyl fluorides weak inhibition Homo sapiens
Sulfonyl fluorides weak inhibition Mus musculus
tribufos inhibition at 0.1 mM Homo sapiens
tribufos inhibition at 0.1 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Mus musculus regulation of platelet-activating factor 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens regulation of platelet-activating factor 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-
blood plasma
-
 Homo sapiens
-
brain
-
 Mus musculus
-
liver
-
 Mus musculus
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testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor Mus musculus 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
platelet-activating factor acetylhydrolase
-
 Mus musculus
platelet-activating factor acetylhydrolase
-
 Homo sapiens