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Literature summary for 3.1.1.47 extracted from

  • Inoue, T.; Sugimoto, A.; Suzuki, Y.; Yamamoto, M.; Tsujimoto, M.; Inoue, K.; Aoki, J.; Arai, H.
    Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans (2004), Proc. Natl. Acad. Sci. USA, 101, 13233-13238.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.47

Cloned(Commentary)

Cloned (Comment) Organism
cloning of paf-1 gene homologue, expression in Escherichia coli Caenorhabditis elegans
cloning of paf-2 gene homologue, expression in Escherichia coli Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information loss of function mutants of the two homologous PAF-AH (II) genes, mutant organisms show defects in epithelial sheet formation, resulting in unsuccessful subsequent morphogenesis with complete penetrance Caenorhabditis elegans
additional information loss of function mutants of the two homologous PAF-AH (II) genes, mutant organisms show defects in epithelial sheet formation, resulting in unsuccessful subsequent morphogenesis with complete penetrance, disruption of paf-2 results in severe impairment of embryonic development, embryos are found to be arrested in the bean stage and fail to elongate Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Caenorhabditis elegans 5829
-
membrane
-
 Caenorhabditis elegans 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Caenorhabditis elegans regulation of platelet-activating factor, essential for epithelial morphogenesis 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
additional information Caenorhabditis elegans hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids ?
-
 ?
additional information Caenorhabditis elegans hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
 product of the paf-1 gene homologue; Bristol strain N2, two homologous PAF-AH (II) genes, named paf-1 and paf-2
-
Caenorhabditis elegans Q22943 product of the paf-2 gene homologue; Bristol strain N2, two homologous PAF-AH (II) genes, named paf-1 and paf-2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information N-myristoylated at the N-terminus Caenorhabditis elegans

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Caenorhabditis elegans

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
-
 Caenorhabditis elegans 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O regulation of platelet-activating factor, essential for epithelial morphogenesis Caenorhabditis elegans 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
additional information hydrolyzes also propionyl and butyloyl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids Caenorhabditis elegans ?
-
 ?
additional information hydrolyzes also propionyl and butyryl groups from phosphoglycerides, and truncated acyl chains derived from oxidative cleavage of long-chain polyunsaturated fatty acyl groups, suggesting that they have a role in scavenging selectively oxidized phospholipid species without acting on structural membrane phospholipids Caenorhabditis elegans ?
-
 ?
additional information no hydrolysis of long acyl chains attached to phosphatidylcholine Caenorhabditis elegans ?
-
 ?
oxidized phosphatidylcholine + H2O
-
 Caenorhabditis elegans ?
-
 ?

Synonyms

Synonyms Comment Organism
PAF-AH (II)
-
 Caenorhabditis elegans
Type II platelet-activating factor-acetylhydrolase
-
 Caenorhabditis elegans