Literature summary for 3.1.1.47 extracted from

Jehle, R.; Schlame, M.; Buttner, C.; Frey, B.; Sinha, P.; Rustow, B.
Platelet-activating factor (PAF)-acetylhydrolase and PAF-like compounds in the lung: effects of hyperoxia (2001), Biochim. Biophys. Acta, 1532, 60-66.

Search for more literature for 3.1.1.47

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	enzyme activity of the bronchoalveolar lavage is reduced in hyperoxia, but not in plasma	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secretion, association to membranes, plasma	Rattus norvegicus	-	-
membrane	cell surface	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O	Rattus norvegicus	i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma	1-alkyl-sn-glycero-3-phosphocholine + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
alveolar cell type II	-	Rattus norvegicus	-
bronchoalveolar lavage	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
macrophage	-	Rattus norvegicus	-
plasma	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	hyperoxemic rats show reduced activity in bronchoalveolar lavage, but not in plasma	Rattus norvegicus
0.47	-	supernatant fraction	Rattus norvegicus
0.55	-	alveolar type II cells and 1000 x g fraction	Rattus norvegicus
0.77	-	macrophages	Rattus norvegicus
0.85	-	100000 x g fraction	Rattus norvegicus
1.32	-	60000 x g fraction	Rattus norvegicus
3.7	-	bronchoalveolar lavage	Rattus norvegicus
27.1	-	plasma	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O	i.e. platelet-activation factor	Rattus norvegicus	1-alkyl-sn-glycero-3-phosphocholine + acetate	-	?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O	i.e. platelet-activation factor, hyperoxemic rats show reduced enzyme activity in bronchoalveolar lavage and slightly increased levels in the plasma	Rattus norvegicus	1-alkyl-sn-glycero-3-phosphocholine + acetate	-	?

Synonyms

Synonyms	Comment	Organism
(PAF)-acetylhydrolase	-	Rattus norvegicus
PAF-AH	-	Rattus norvegicus
platelet-activating factor acetylhydrolase	-	Rattus norvegicus

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Release 2023.1 (January 2023)