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Literature summary for 3.1.1.4 extracted from

  • Yamamoto, K.; Miki, Y.; Sato, H.; Murase, R.; Taketomi, Y.; Murakami, M.
    Secreted phospholipase A2 specificity on natural membrane phospholipids (2017), Methods Enzymol., 583, 101-117 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus sPLA2-IIE preferentially hydrolyzes the minor lipoprotein phospholipids, phosphatidylethanolamine and phosphatidylserine, with no fatty acid selectivity ?
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?
additional information Mus musculus sPLA2-X secreted from sperm acrosomes selectively hydrolyzes docosahexaenoic acid- or docosapentaenoic acid-containing phosphatidylcholine in the sperm membrane to release docosahexaenoic acid, docosapentaenoic acid, and lysophosphatidylcholine ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus Q9QZT4
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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Mus musculus
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dendritic cell secreted phospholipase A2-IID is preferentially and abundantly expressed in dendritic cells in lymphoid organs Mus musculus
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keratinocyte sPLA2-IIF is expressed in terminally differentiated keratinocytes in the suprabasal epidermis and markedly increased in psoriatic skin Mus musculus
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semen enzyme is secreted from sperm acrosomes Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sPLA2-IIE preferentially hydrolyzes the minor lipoprotein phospholipids, phosphatidylethanolamine and phosphatidylserine, with no fatty acid selectivity Mus musculus ?
-
?
additional information sPLA2-X secreted from sperm acrosomes selectively hydrolyzes docosahexaenoic acid- or docosapentaenoic acid-containing phosphatidylcholine in the sperm membrane to release docosahexaenoic acid, docosapentaenoic acid, and lysophosphatidylcholine Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
secreted phospholipase A2
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Mus musculus
sPLA2
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Mus musculus
sPLA2-IID
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Mus musculus
sPLA2-IIE
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Mus musculus
sPLA2-IIF
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Mus musculus
sPLA2-X
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Mus musculus

General Information

General Information Comment Organism
malfunction mice deficient in secreted phospholipase A2 IIF are protected from epidermal hyperplasia in psoriasis, contact dermatitis, and skin cancer, where ethanolamine lysoplasmalogen is selectively reduced in the KO skin relative to wild-type skin Mus musculus
malfunction when fed a high-fat diet, sPLA2-IIE-deficient mice display lower weight gain, adiposity, and fatty liver, accompanied by alterations in plasma lipoprotein profiles Mus musculus
physiological function adipocyte inducible sPLA2-IIE targets phospholipids in lipoproteins Mus musculus
physiological function role in adaptive immunity. secreted phospholipase A2-IID preferentially hydrolyzes arachidonic acid- or docosahexaenoic acid-containing phosphatidylethanolamine in lymph nodes, thereby mobilizing arachidonic acid- and particularly docosahexaenoic acid-derived antiinflammatory lipid mediators that attenuate the Th1-mediated immunity Mus musculus
physiological function secreted phospholipase A2 IIF referentially hydrolyzes plasmalogen secreted from keratinocytes to produce lysoplasmalogen, which in turn promotes the hyperproliferation and activation of keratinocytes, leading to aggravation of epidermal-hyperplasic disorders. sPLA2-IIF transgenic mice spontaneously developed psoriasis-like epidermal hyperplasia and alopecia, with preferential hydrolysis of DHA-containing phosphatidylethanolamine to give rise to acyl and plasmalogen (P-) forms of lysophosphatidylethanolamine molecular species in addition to (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate (DHA) Mus musculus
physiological function the enzyme plays a role as an omega3 PUFA mobilizer. sPLA2-X secreted from sperm acrosomes selectively hydrolyzes docosahexaenoic acid- or docosapentaenoic acid-containing phosphatidylcholine in the sperm membrane to release docosahexaenoic acid, docosapentaenoic acid, and lysophosphatidylcholine, and the defective fertilization ability of sPLA2-X KO sperm was corrected by these lipids (docosapentaenoic acid in particular), suggesting the importance of the sPLA2-X-driven docosapentaenoic acid for successful fertilization Mus musculus