Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a potential drug target for developing a selective therapeutic agent for the treatment of psoriasis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in insect cells (Sf9) | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
vapor diffusion at 4°C, X-ray structures of human cPLA2delta, capturing an apo state, and in complex with a substrate-like inhibitor | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K554A/D555A/K556A | to crystallize apo-cPLA2d, three surface mutations (K554A, D555A, and K556A) are introduced to decrease surface entropy | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86XP0 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
GIVD cPLA2delta | - |
Homo sapiens |
PLA2G4D | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme generates lipid second messengers through hydrolysis of membrane-associated glycerophospholipids | Homo sapiens |