Literature summary for 3.1.1.4 extracted from

Batchu, K.C.; Haenninen, S.; Jha, S.K.; Jeltsch, M.; Somerharju, P.
Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro (2016), Biochim. Biophys. Acta, 1861, 1597-1604 .

Search for more literature for 3.1.1.4

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P47712	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	while favorable accommodation of the substrate in the active site greatly contributes to the preferential hydrolysis of arachidonic acid-containing glycerophospholipids by cytosolic phospholipase A2 alphacPLA2alpha also the efflux of the substrate from a bilayer plays a significant role. When the substrate lacks an arachidonic acid residue, efflux from a bilayer appears to be the key rate-limiting step of hydrolysis. Promiscuous binding of the acyl chains of a glycerophospholipid to the active site of cytosolic phospholipase A2 alpha most probably explains why the enzyme has both PLA1 and PLA2 activities	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cPLA2alpha	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme plays a key role in signaling in mammalian cells by releasing arachidonic acid from glycerophospholipids	Homo sapiens

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Release 2023.1 (January 2023)