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Literature summary for 3.1.1.4 extracted from

  • Xu, S.; Pei, R.; Guo, M.; Han, Q.; Lai, J.; Wang, Y.; Wu, C.; Zhou, Y.; Lu, M.; Chen, X.
    Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly (2012), J. Virol., 86, 13025-13037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
methyl arachidonyl fluorophosphonate induces hepatitis C viral replication deficiency, not reversible by arachidonic acid in vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol the enzyme colocalizes with NS4B and HCV replication complexes Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Homo sapiens
-
 1-acylglycerophosphocholine + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Lunet-Con1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + H2O
-
 Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase A2 gamma
-
 Homo sapiens
PLA2G4C
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of the enzyme in hepatitis C virus-infected cells or hepatitis C virus replicon-containing cells by small interfering RNA significantly suppresses hepatitis C virus replication and assembly, not the viral entry, overview. In addition, the chemical inhibitor methyl arachidonyl fluorophosphonate, which specifically inhibits phospholipase A2, reduces hepatitis C virus replication and assembly. The membranous web structure formation is defective Homo sapiens
physiological function the cytosolic phospholipase A2 gamma contributes to membranous web formation, hepatitis C virus replication, and assembly. The PLA2G4C gene is identified as a host gene with upregulated expression upon hepatitis C virus infection. The enzyme colocalizes with the hepatitis C virus proteins NS4B and NS5A in cells infected with JFH-1 and interacts with NS4B. In addition, the enzyme is able to transport the hepatitis C virus nonstructural proteins from replication sites to lipid droplets, the site for hepatitis C virus assembly Homo sapiens